Hanahan and weinberg described the hallmarks or features of cancer, such as the cancer cells capacity for development and progression of clinically manifest cancer. Cancer is not defined as a single disease, but a heterogeneous group of diseases, characterized by the accumulation of mutations in the genome of cells, to the point where these mutations affect the various functions at the molecular, cellular, tissue, and systemic levels, with the consequent death of the patient. Molecular biology of head and neck tumors in cancer. Knowledge and understanding of the nature of the dna alterations is essential to the comprehension of the carcinogenic process at both a molecular and human scale.
Cancer is a group of diseases characterized by an autonomous proliferation of neoplastia cells which have a number of alterations, including mutations and genetic instability. Gerner departments of radiation oncology cancer biology section molecular and cellular biology biochemistry and molecular biophysics cancer biology graduate program the university of arizona tuscon, arizona. Fifth edition, edited by vincent t devita, samuel hellman, steven. Cancer is a major human health problem worldwide and is the second leading cause of death in the united states 1. Os corpos mais escuros e alongados sao mitocondrias. Cellular functions are controlled by proteins, and because these proteins are encoded by dna organized into genes, molecular studies have shown that cancer is. The third is that loss of genomic stability is a key molecular step in cancer formation 6. Biologia molecular desde mendel hasta las moleculas. Breast cancer subtypes that differ in their genetic. The six traits are to maintain proliferative signaling. Breast cancer is a common disease affecting approximately 1 in 10 women at some time in their lives. Biologia molecular del cancer 2010 linkedin slideshare.
Cervical cancer is a leading cause of cancer deaths in developing countries because of high hpv infection rates and lack of comprehensive cervical pap smear testing of susceptible women. Apr 21, 2016 breast cancer is the most common cancer among women worldwide. Molecular diagnostics is a dynamic area in constant development that has revolutionized the diagnosis in health care centers. Great scientific, economical, and organizational efforts are in place to understand the causes of onset, identify the critical molecular players of progression, and define new lines of intervention providing more benefits and less toxicity. Gurrola diaz c gurrola diaz, carmen magdalena bases moleculares del cancer. Detection and quantification of genetic material in a sample has shown an enormous impact on all areas of health, with emphasis on infectious diseases and cancer. Summary breast cancer is classified based on clinical stage, cellular morphology and immunohistochemical analysis. Biologia celular y angiogenesis molecular del cancer metastasis. Biologia molecular en oncologia clinica las condes. This dysregulation of the cell cycle results in the formation of a tumor, from which cancer cells disseminate to distant organs, finally bringing about patient death. They develop genetically engineered mouse models of cancer to understand the progression. Jul 04, 2016 biologia celular e molecular figura 1.
Fda clears breast cancer specific molecular prognostic. Asi, puede haber individuos con predisposicion alta, mediana y baja. The fourth is that hereditary cancer syndromes frequently correspond to germ line forms of key genetic defects whose somatic occurrences drive the. Biologia molecular, concepto, objetivos, principios.
Undifferentiated carcinomas and medullary thyroid carcinomas are less common. Biologia molecular del cancer y las nuevas herramientas en. Most carcinomas are welldifferentiated cancers originating from the follicular epithelium, and are subdivided into papillary and follicular carcinomas. The accumulation of this basic knowledge has established that cancer is a variety of distinct diseases and that defective. Biologia celular y angiogenesis molecular del cancer. Oncogenic hpv dna is found in over 95% of invasive cervical cancers worldwide. Salazar montes a, sandoval rodriguez a, armendariz borunda j eds. Cellular functions are controlled by proteins, and because these proteins are encoded by dna organized into genes, molecular studies have shown that cancer is a paradigm. Moreover, it is not a single disease but is characterised by distinct pathological types with.
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